HEXA monoclonal antibody (M06A), clone 3D1
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More Files
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Western Blot (Tissue lysate)
HEXA monoclonal antibody (M06A), clone 3D1. Western Blot analysis of HEXA expression in human kidney.
Western Blot (Cell lysate)
HEXA monoclonal antibody (M06A), clone 3D1. Western Blot analysis of HEXA expression in HeLa.
Western Blot (Transfected lysate)
Western Blot analysis of HEXA expression in transfected 293T cell line by HEXA monoclonal antibody (M06A), clone 3D1.
Lane 1: HEXA transfected lysate(60.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot detection against Immunogen (83.93 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant HEXA.
Immunogen
HEXA (AAH18927, 1 a.a. ~ 529 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MTSSRLWFSLLLAAAFAGRATALWPWPQNFQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPEIQDFMRKKGFGEDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKIQPDTIIQVWREDIPVNYMKELELVTKAGFRALLSAPWYLNRISYGPDWKDFYVVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSNKLTSDLTFAYERLSHFRCELLRRGVQAQPLNVGFCEQEFEQT
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (83.93 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
HEXA monoclonal antibody (M06A), clone 3D1. Western Blot analysis of HEXA expression in human kidney.Western Blot (Cell lysate)
HEXA monoclonal antibody (M06A), clone 3D1. Western Blot analysis of HEXA expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of HEXA expression in transfected 293T cell line by HEXA monoclonal antibody (M06A), clone 3D1.
Lane 1: HEXA transfected lysate(60.7 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — HEXA
Entrez GeneID
3073GeneBank Accession#
BC018927Protein Accession#
AAH18927Gene Name
HEXA
Gene Alias
MGC99608, TSD
Gene Description
hexosaminidase A (alpha polypeptide)
Gene Ontology
HyperlinkGene Summary
This gene encodes the alpha subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Alpha subunit gene mutations lead to Tay-Sachs disease (GM2-gangliosidosis type I). [provided by RefSeq
Other Designations
GM2 gangliosidosis|N-acetyl-beta-glucosaminidase|Tay Sachs disease|beta-N-acetylhexosaminidase|hexosaminidase A
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Interactome
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Pathway
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Disease
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