HSD17B10 MaxPab mouse polyclonal antibody (B01)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human HSD17B10 protein.
Immunogen
HSD17B10 (NP_004484.1, 1 a.a. ~ 261 a.a) full-length human protein.
Sequence
MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of HSD17B10 expression in transfected 293T cell line (H00003028-T01) by HSD17B10 MaxPab polyclonal antibody.
Lane 1: HADH2 transfected lysate(28.71 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to HADH2 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — HSD17B10
Entrez GeneID
3028GeneBank Accession#
NM_004493.2Protein Accession#
NP_004484.1Gene Name
HSD17B10
Gene Alias
17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
Gene Description
hydroxysteroid (17-beta) dehydrogenase 10
Gene Ontology
HyperlinkGene Summary
This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. The protein has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq
Other Designations
17-beta-hydroxysteroid dehydrogenase type 10|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|AB-binding alcohol dehydrogenase|OTTHUMP00000023348|OTTHUMP00000023349|amyloid-beta binding polypeptide|amyloid-beta peptide binding alcohol dehydrogenase|mental reta
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Interactome
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Pathway
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Publication Reference
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Enhanced levels of mitochondrial enzyme 17b-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis.
Kristofikova Z, Bockova M, Hegnerova K, Bartos A, Klaschka J, Ricny J, Ripova D, Homola J.
Molecular BioSystems 2009 Oct; 5(10):1174.
Application:ELISA, Human, Human cerebrospinal fluid.
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Enhanced levels of mitochondrial enzyme 17b-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis.
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