XRCC6 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human XRCC6 full-length ORF ( AAH08343.1, 1 a.a. - 609 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKVTKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELLEALTKHFQD
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
92.73
Interspecies Antigen Sequence
Mouse (83); Rat (83)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — XRCC6
Entrez GeneID
2547GeneBank Accession#
BC008343Protein Accession#
AAH08343.1Gene Name
XRCC6
Gene Alias
CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Gene Description
X-ray repair complementing defective repair in Chinese hamster cells 6
Omim ID
152690Gene Ontology
HyperlinkGene Summary
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq
Other Designations
ATP-dependent DNA helicase II, 70 kDa subunit|CTC box binding factor 75 kDa subunit|Ku autoantigen p70 subunit|Ku autoantigen, 70kDa|OTTHUMP00000028581|thyroid autoantigen 70kD (Ku antigen)|thyroid autoantigen 70kDa (Ku antigen)|thyroid-lupus autoantigen
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Interactome
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Pathway
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Disease
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Publication Reference
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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Hikari Tanaka, Kanoh Kondo, Kyota Fujita, Hidenori Homma, Kazuhiko Tagawa, Xiaocen Jin, Meihua Jin, Yuki Yoshioka, Sumire Takayama, Hitomi Masuda, Rie Tokuyama, Yukoh Nakazaki, Takashi Saito, Takaomi Saido, Shigeo Murayama, Teikichi Ikura, Nobutoshi Ito, Yu Yamamori, Kentaro Tomii, Marco E Bianchi, Hitoshi Okazawa.
Communications Biology 2021 Oct; 4(1):1175.
Application:KA, Human, Human Kinase Protein.
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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
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