ACSL1 monoclonal antibody (M02), clone 3G4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant ACSL1.
Immunogen
ACSL1 (NP_001986, 48 a.a. ~ 145 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTA
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (79); Rat (78)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.52 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged ACSL1 is approximately 0.3ng/ml as a capture antibody.ELISA
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Gene Info — ACSL1
Entrez GeneID
2180GeneBank Accession#
NM_001995Protein Accession#
NP_001986Gene Name
ACSL1
Gene Alias
ACS1, FACL1, FACL2, LACS, LACS1, LACS2
Gene Description
acyl-CoA synthetase long-chain family member 1
Omim ID
152425Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. [provided by RefSeq
Other Designations
fatty-acid-Coenzyme A ligase, long-chain 1|fatty-acid-Coenzyme A ligase, long-chain 2|lignoceroyl-CoA synthase|long-chain acyl-CoA synthetase 1|long-chain acyl-CoA synthetase 2|long-chain fatty-acid-coenzyme A ligase 1|palmitoyl-CoA ligase 2|paltimoyl-CoA
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Interactome
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Pathway
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Disease
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Publication Reference
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Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs).
Maria A. Recuero-Checa, Manu Sharma, Constance Lau, Paul A. Watkins, Charlotte A. Gaydos and Deborah Dean.
Scientific Reports 2016 Mar; 6:23148.
Application:IF, Human, HeLa cells.
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Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study.
Xu WD, Yang XY, Li DH, Zheng KD, Qiu PC, Zhang W, Li CY, Lei KF, Yan GQ, Jin SW, Wang JG.
Journal of Proteomics 2015 Jan; 113:57.
Application:WB, Human, Ligament, Fibroblast-like ligament cells.
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Fatty acid transport and activation and the expression patterns of genes involved in fatty acid trafficking.
Sandoval A, Fraisl P, Arias-Barrau E, DiRusso CD, Singer D, Sealls W, Black PN.
Archives of Biochemistry and Biophysics 2008 Jun; 477(2):363.
Application:WB-Ce, Human, Caco-2, HepG2 cells.
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Chlamydia trachomatis growth and development requires the activity of host Long-chain Acyl-CoA Synthetases (ACSLs).
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