F8 (Human) Recombinant Protein (Q01)
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Specification
Product Description
Human F8 partial ORF ( NP_000123, 213 a.a. - 312 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
KFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITF
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.74
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — F8
Entrez GeneID
2157GeneBank Accession#
NM_000132Protein Accession#
NP_000123Gene Name
F8
Gene Alias
AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Gene Description
coagulation factor VIII, procoagulant component
Omim ID
306700Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq
Other Designations
OTTHUMP00000061446|OTTHUMP00000196174|coagulation factor VIII|coagulation factor VIIIc|factor VIII F8B|procoagulant component
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Interactome
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