F8 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human F8 protein.
Immunogen
F8 (NP_063916.1, 1 a.a. ~ 216 a.a) full-length human protein.
Sequence
MRIQDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of F8 expression in transfected 293T cell line (H00002157-T01) by F8 MaxPab polyclonal antibody.
Lane 1: F8 transfected lysate(23.76 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — F8
Entrez GeneID
2157GeneBank Accession#
NM_019863.2Protein Accession#
NP_063916.1Gene Name
F8
Gene Alias
AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Gene Description
coagulation factor VIII, procoagulant component
Omim ID
306700Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq
Other Designations
OTTHUMP00000061446|OTTHUMP00000196174|coagulation factor VIII|coagulation factor VIIIc|factor VIII F8B|procoagulant component
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Interactome
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Disease
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