F7 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-F7 full-length
Host
Human
Theoretical MW (kDa)
49.3
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-F7 antibody (H00002155-B01) by Western Blots.
SDS-PAGE Gel
F7 transfected lysate.
Western Blot
Lane 1: F7 transfected lysate ( 49.3 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — F7
Entrez GeneID
2155GeneBank Accession#
NM_019616.1Protein Accession#
-Gene Name
F7
Gene Alias
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Gene Description
coagulation factor VII (serum prothrombin conversion accelerator)
Omim ID
227500Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq
Other Designations
FVII coagulation protein|OTTHUMP00000018733|OTTHUMP00000018734|coagulation factor VII|eptacog alfa
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Interactome
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Disease
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