EXT1 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Western Blot (Tissue lysate)
EXT1 MaxPab rabbit polyclonal antibody. Western Blot analysis of EXT1 expression in human liver.
Western Blot (Transfected lysate)
Western Blot analysis of EXT1 expression in transfected 293T cell line (H00002131-T01) by EXT1 MaxPab polyclonal antibody.
Lane 1: EXT1 transfected lysate(86.30 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to EXT1 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human EXT1 protein.
Immunogen
EXT1 (NP_000118.2, 1 a.a. ~ 746 a.a) full-length human protein.
Sequence
MQAKKRYFILLSAGSCLALLFYFGGLQFRASRSHSRREEHSGRNGLHHPSPDHFWPRFPDALRPFVPWDQLENEDSSVHISPRQKRDANSSIYKGKKCRMESCFDFTLCKKNGFKVYVYPQQKGEKIAESYQNILAAIEGSRFYTSDPSQACLFVLSLDTLDRDQLSPQYVHNLRSKVQSLHLWNNGRNHLIFNLYSGTWPDYTEDVGFDIGQAMLAKASISTENFRPNFDVSIPLFSKDHPRTGGERGFLKFNTIPPLRKYMLVFKGKRYLTGIGSDTRNALYHVHNGEDVVLLTTCKHGKDWQKHKDSRCDRDNTEYEKYDYREMLHNATFCLVPRGRRLGSFRFLEALQAACVPVMLSNGWELPFSEVINWNQAAVIGDERLLLQIPSTIRSIHQDKILALRQQTQFLWEAYFSSVEKIVLTTLEIIQDRIFKHISRNSLIWNKHPGGLFVLPQYSSYLGDFPYYYANLGLKPPSKFTAVIHAVTPLVSQSQPVLKLLVAAAKSQYCAQIIVLWNCDKPLPAKHRWPATAVPVVVIEGESKVMSSRFLPYDNIITDAVLSLDEDTVLSTTEVDFAFTVWQSFPERIVGYPARSHFWDNSKERWGYTSKWTNDYSMVLTGAAIYHKYYHYLYSHYLPASLKNMVDQLANCEDILMNFLVSAVTKLPPIKVTQKKQYKETMMGQTSRASRWADPDHFAQRQSCMNTFASWFGYMPLIHSQMRLDPVLFKDQVSILRKKYRDIERL
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (99)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
EXT1 MaxPab rabbit polyclonal antibody. Western Blot analysis of EXT1 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of EXT1 expression in transfected 293T cell line (H00002131-T01) by EXT1 MaxPab polyclonal antibody.
Lane 1: EXT1 transfected lysate(86.30 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to EXT1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — EXT1
Entrez GeneID
2131GeneBank Accession#
NM_000127Protein Accession#
NP_000118.2Gene Name
EXT1
Gene Alias
EXT, LGCR, LGS, TRPS2, ttv
Gene Description
exostosin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes an endoplasmic reticulum-resident type II transmembrane glycosyltransferase involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type I form of multiple exostoses. [provided by RefSeq
Other Designations
Langer-Giedion syndrome chromosome region|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase|OTTHUMP00000066043|exostosin 1|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase
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Interactome
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Pathway
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Disease
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Publication Reference
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Variations in metabolic enzymes cause differential changes of heparan sulfate and hyaluronan in high glucose treated cells on chip.
Jinhua Wei, Dongdong Liu, Tong Xu, Limeng Zhu, Siming Jiao, Xubing Yuan, Zhuo A Wang, Jianjun Li, Yuguang Du.
International Journal of Biological Macromolecules 2023 Sep; 253(Pt 1):126627.
Application：WB, Human, HUVEC cells.
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A Splice Mutation and mRNA Decay of EXT2 Provoke Hereditary Multiple Exostoses.
Tian C, Yan R, Wen S, Li X, Li T, Cai Z, Li X, Du H, Chen H.
PLoS One 2014 Apr; 9(4):e94848.
Application：WB-Ti, Human, Bone.
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Variations in metabolic enzymes cause differential changes of heparan sulfate and hyaluronan in high glucose treated cells on chip.
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