Products

Western Blot (Transfected lysate)

Western Blot analysis of DGUOK expression in transfected 293T cell line by DGUOK monoclonal antibody (M02), clone 3E9.

Lane 1: DGUOK transfected lysate(32.056 KDa).
Lane 2: Non-transfected lysate.

Western Blot (Recombinant protein)

ELISA

RNAi Knockdown (Antibody validated)

Western blot analysis of DGUOK over-expressed 293 cell line, cotransfected with DGUOK Validated Chimera RNAi ( Cat # H00001716-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with DGUOK monoclonal antibody (M02), clone 3E9 (Cat # H00001716-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

Entrez GeneID

1716

GeneBank Accession#

NM_001929

Protein Accession#

NP_001920

Gene Name

DGUOK

Gene Alias

dGK

Gene Description

deoxyguanosine kinase

Omim ID

251880 601465

Gene Ontology

Hyperlink

Gene Summary

In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000160251|OTTHUMP00000160252|deoxyguanosine kinase, mitochondrial