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- Home > Products > siRNA/Chimera > Pre-design Chimera > Apoptosis > GADD45A Pre-design Chimera RNAi
GADD45A Pre-design Chimera RNAi
- Catalog # : H00001647-R01
- Visit Frequency :
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- Price
- In Stock
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- 10 nmol
- USD $ 239
- order now, ship in 2 weeks
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- 20 nmol
- USD $ 289
- order now, ship in 2 weeks
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Email : sales@abnova.com
Phone : +1-909-992-0619 (new)
Fax : +1-909-992-3401- Products will be shipped directly to the customer.
- Specification
- Product Description:
- Homo sapiens growth arrest and DNA-damage-inducible, alpha (GADD45A), mRNA.
- Reactivity:
- Human
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_001924
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1647
- Gene Name:
- GADD45A
- Gene Alias:
- DDIT1,GADD45
- Gene Description:
- growth arrest and DNA-damage-inducible, alpha
- Omim ID:
- 126335
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. [provided by RefSeq
- Other Designations:
- DNA damage-inducible transcript 1,DNA damage-inducible transcript-1,DNA-damage-inducible transcript 1,OTTHUMP00000010979,growth arrest and DNA-damage-inducible 45 alpha
- Related Disease
- Ataxia telangiectasia
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- Breast Neoplasms
- Chronic Disease
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- Genetic Predisposition to Disease
- Lung Neoplasms
- Microsatellite Instability
- Neoplasms, Glandular and Epithelial
- Occupational Diseases
- Ovarian cancer
- Ovarian Neoplasms
- Pulmonary Disease, Chronic Obstructive
- Schizophrenia
- Schizophrenia, Paranoid
