Proximity Ligation Analysis of protein-protein interactions between MAP2K6 and GADD45A HeLa cells were stained with anti-MAP2K6 rabbit purified polyclonal 1:1200 and anti-GADD45A mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. [provided by RefSeq
DNA damage-inducible transcript 1,DNA damage-inducible transcript-1,DNA-damage-inducible transcript 1,OTTHUMP00000010979,growth arrest and DNA-damage-inducible 45 alpha