DCK rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human DCK peptide using ARM Technology.
Immunogen
A synthetic peptide of human DCK is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human DCK peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — DCK
Entrez GeneID
1633GeneBank Accession#
DCKGene Name
DCK
Gene Alias
MGC117410, MGC138632
Gene Description
deoxycytidine kinase
Omim ID
125450Gene Ontology
HyperlinkGene Summary
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
- Acute Disease
- Adenocarcinoma
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Kidney Failure
- Leukemia
- Neoplasms
- Neutropenia
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