Immunoprecipitation of AKR1C4 transfected lysate using anti-AKR1C4 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with AKR1C4 MaxPab mouse polyclonal antibody (B01) (H00001109-B01).
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq
3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase 4,OTTHUMP00000018997,aldo-keto reductase family 1, member C4,chlordecone reductase,dihydrodiol dehydrogenase 4,dihydrodiol dehydrogenase isozyme DD4,type I 3-alpha-hydroxysteroid dehydrogenase