CASP10 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human CASP10 partial ORF ( NP_116756, 1 a.a. - 110 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
37.84
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CASP10
Entrez GeneID
843GeneBank Accession#
NM_032974Protein Accession#
NP_116756Gene Name
CASP10
Gene Alias
ALPS2, FLICE2, MCH4
Gene Description
caspase 10, apoptosis-related cysteine peptidase
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
FADD-like ICE2|Fas-associated death domain protein|ICE-like apoptotic protease 4|apoptotic protease MCH-4|caspase 10|caspase 10, apoptosis-related cysteine protease|interleukin-1B-converting enzyme 2
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Interactome
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Pathway
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Disease
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