CASP4 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CASP4 full-length ORF ( AAH17839, 1 a.a. - 377 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
67.21
Interspecies Antigen Sequence
Mouse (60); Rat (59)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CASP4
Entrez GeneID
837GeneBank Accession#
BC017839Protein Accession#
AAH17839Gene Name
CASP4
Gene Alias
ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Gene Description
caspase 4, apoptosis-related cysteine peptidase
Omim ID
602664Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
apoptotic cysteine protease Mih1/TX|caspase 4|caspase 4, apoptosis-related cysteine protease
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Interactome
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Disease
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