Products

Western Blot (Tissue lysate)

Western Blot (Transfected lysate)

Immunoprecipitation

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

CASP3

Gene Alias

CPP32, CPP32B, SCA-1

Gene Description

caspase 3, apoptosis-related cysteine peptidase

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq

Other Designations

OTTHUMP00000165054|PARP cleavage protease|SREBP cleavage activity 1|Yama|apopain|caspase 3|caspase 3, apoptosis-related cysteine protease|cysteine protease CPP32|procaspase3