CALCR monoclonal antibody (M01), clone 2F7
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CALCR.
Immunogen
CALCR (NP_001733.1, 394 a.a. ~ 474 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
CNNEVQTTVKRQWAQFKIQWNQRWGRRPSNRSARAAAAAAEAGDIPIYICHQELRNEPANNQGEESAEIIPLNIIEQESSA
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (34.65 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged CALCR is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — CALCR
Entrez GeneID
799GeneBank Accession#
NM_001742Protein Accession#
NP_001733.1Gene Name
CALCR
Gene Alias
CRT, CTR, CTR1
Gene Description
calcitonin receptor
Gene Ontology
HyperlinkGene Summary
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000025217|OTTHUMP00000162535
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Interactome
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Pathway
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Disease
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Publication Reference
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Identification of the calcitonin receptor in osteoarthritic chondrocytes.
Segovia-Silvestre T, Bonnefond C, Sondergaard BC, Christensen T, Karsdal MA, Bay-Jensen AC.
BMC Research Notes 2011 Oct; 4(1):407.
Application:WB-Ce, Human, Chondrocytes.
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Identification of the calcitonin receptor in osteoarthritic chondrocytes.
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