BRCA2 monoclonal antibody (M01), clone 3D12
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More Files
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant BRCA2.
Immunogen
BRCA2 (NP_000050, 3319 a.a. ~ 3418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
SPQMTPFKKFNEISLLESNSIADEELALINTQALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNKQDTITTKKYI
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (48); Rat (50)
Isotype
IgG3 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged BRCA2 is 0.03 ng/ml as a capture antibody.ELISA
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Gene Info — BRCA2
Entrez GeneID
675GeneBank Accession#
NM_000059Protein Accession#
NP_000050Gene Name
BRCA2
Gene Alias
BRCC2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1
Gene Description
breast cancer 2, early onset
Gene Ontology
HyperlinkGene Summary
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq
Other Designations
BRCA1/BRCA2-containing complex, subunit 2|OTTHUMP00000018803|OTTHUMP00000042401|breast and ovarian cancer susceptibility gene, early onset|breast cancer 2 tumor suppressor|breast cancer susceptibility protein BRCA2
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Interactomes
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Pathways
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Diseases
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