BMPR2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human BMPR2 partial ORF ( NP_001195.2, 939 a.a. - 1037 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
NSLDLSATNVLDGSSIQIGESTQDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAEGGTATTMVSKDIGMNC
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — BMPR2
Entrez GeneID
659GeneBank Accession#
NM_001204Protein Accession#
NP_001195.2Gene Name
BMPR2
Gene Alias
BMPR-II, BMPR3, BMR2, BRK-3, FLJ41585, FLJ76945, PPH1, T-ALK
Gene Description
bone morphogenetic protein receptor, type II (serine/threonine kinase)
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq
Other Designations
BMP type II receptor|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|primary pulmonary hypertension 1|serine/threonine kinase|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4
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Interactome
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Pathway
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Disease
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Publication Reference
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Bone morphogenetic protein receptor expressions in the adult rat brain.
Miyagi M, Mikawa S, Hasegawa T, Sho K, Matsuyama Y, Sato K.
Neuroscience 2011 Mar; 176:93.
Application:ELISA, Antibody.
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Bone morphogenetic protein receptor expressions in the adult rat brain.
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