BLMH polyclonal antibody (A01)
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant BLMH.
Immunogen
BLMH (NP_000377, 356 a.a. ~ 454 a.a) partial recombinant protein with GST tag.
Sequence
NMNKAERLTFGESLMTHAMTFTAVSEKDDQDGAFTKWRVENSWGEDHGHKGYLCMTDEWFSEYVYEVVVDRKHVPEEVLAVLEQEPIILPAWDPMGALA
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
BLMH polyclonal antibody (A01), Lot # 060111JC01 Western Blot analysis of BLMH expression in 293 ( Cat # L026V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — BLMH
Entrez GeneID
642GeneBank Accession#
NM_000386Protein Accession#
NP_000377Gene Name
BLMH
Gene Alias
BH, BMH
Gene Description
bleomycin hydrolase
Gene Ontology
HyperlinkGene Summary
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. [provided by RefSeq
Other Designations
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Interactome
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Disease
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Publication Reference
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Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.
Masuda Y, Noguchi K, Segawa H, Tanaka N, Katayama K, Mitsuhashi J, Sugimoto Y.
Biochemical and Biophysical Research Communications 2011 Nov; 415(2):305.
Application:WB-Tr, Human, HEK293 cells.
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Paradoxical function for the receptor for advanced glycation end products in mouse models of pulmonary fibrosis.
Englert JM, Kliment CR, Ramsgaard L, Milutinovic PS, Crum L, Tobolewski JM, Oury TD.
International Journal of Clinical and Experimental Pathology 2011 Mar; 4(3):241.
Application:WB, Mouse, Lung.
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Novel regulatory role for Kaposi's sarcoma-associated herpesvirus-encoded vFLIP in chemosensitization to bleomycin.
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