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- Home > Products > siRNA/Chimera > Pre-design Chimera > Enzyme > Kinase > BCR Pre-design Chimera RNAi
BCR Pre-design Chimera RNAi
- Catalog # : H00000613-R04
- Visit Frequency :
- Size
- Price
- In Stock
- Availability
- Cart
- 10 nmol
- USD $ 239
- order now, ship in 2 weeks
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- 20 nmol
- USD $ 289
- order now, ship in 2 weeks
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- The price is valid only in USA. Please select country.
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Email : sales@abnova.com
Phone : +1-909-992-0619 (new)
Fax : +1-909-992-3401- Products will be shipped directly to the customer.
- Specification
- Product Description:
- Homo sapiens breakpoint cluster region (BCR), transcript variant 2, mRNA.
- Reactivity:
- Human
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_021574
- Target Region:
- Coding sequence
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 613
- Gene Name:
- BCR
- Gene Alias:
- ALL,BCR-ABL1,BCR1,CML,D22S11,D22S662,FLJ16453,PHL
- Gene Description:
- breakpoint cluster region
- Gene Ontology:
- Hyperlink
- Gene Summary:
- A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- bcr-abl1 e14a3 chimeric protein
- Interactome
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Angina Pectoris, Variant
- Bipolar Disorder
- Brief Psychiatric Rating Scale
- Chromosome Breakage
- Coronary Vasospasm
- Depressive Disorder, Major
- Genetic Predisposition to Disease
- Leukemia, chronic myeloid
- Leukemia, Myelocytic, Acute
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukemia, Myeloid, Chronic
- Lung Neoplasms
- Pulmonary Disease, Chronic Obstructive
- Small Cell Lung Carcinoma
- Tobacco Use Disorder
- Urinary Bladder Neoplasms
- Werner syndrome
