ATIC MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of ATIC expression in transfected 293T cell line (H00000471-T02) by ATIC MaxPab polyclonal antibody.
Lane 1: ATIC transfected lysate(64.60 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of ATIC transfected lysate using anti-ATIC MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with ATIC purified MaxPab mouse polyclonal antibody (B01P) (H00000471-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human ATIC protein.
Immunogen
ATIC (NP_004035.2, 1 a.a. ~ 592 a.a) full-length human protein.
Sequence
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFTHTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINLCDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPISAAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKTGVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDAFFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of ATIC expression in transfected 293T cell line (H00000471-T02) by ATIC MaxPab polyclonal antibody.
Lane 1: ATIC transfected lysate(64.60 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of ATIC transfected lysate using anti-ATIC MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with ATIC purified MaxPab mouse polyclonal antibody (B01P) (H00000471-B01P). -
Gene Info — ATIC
Entrez GeneID
471GeneBank Accession#
NM_004044.4Protein Accession#
NP_004035.2Gene Name
ATIC
Gene Alias
AICAR, AICARFT, FLJ93545, IMPCHASE, PURH
Gene Description
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Gene Ontology
HyperlinkGene Summary
This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq
Other Designations
AICARFT/IMPCHASE
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Interactome
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Pathway
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Disease
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