ASAH1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ASAH1 full-length ORF ( NP_808592.1, 1 a.a. - 395 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPMLKVIVNSLKNMINTFVPSGKVMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDAMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
71
Interspecies Antigen Sequence
Mouse (79); Rat (82)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ASAH1
Entrez GeneID
427GeneBank Accession#
NM_177924.1Protein Accession#
NP_808592.1Gene Name
ASAH1
Gene Alias
AC, ASAH, FLJ21558, FLJ22079, PHP, PHP32
Gene Description
N-acylsphingosine amidohydrolase (acid ceramidase) 1
Omim ID
228000Gene Ontology
HyperlinkGene Summary
This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
N-acylsphingosine amidohydrolase 1|OTTHUMP00000122482|acylsphingosine deacylase|putative 32 kDa heart protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
Huabin Zhu, John D Klement, Chunwan Lu, Priscilla S Redd, Dafeng Yang, Alyssa D Smith, Dakota B Poschel, Juan Zou, Ding Liu, Peng George Wang, David Ostrov, Nicolas Coant, Yusuf A Hannun, Aaron H Colby, Mark W Grinstaff, Kebin Liu.
Journal of immunology 2021 Mar; 206(6):1395.
Application：Enzyme, Recombinant proteins.
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Clinical Utility of Serum Autoantibodies Detected by Protein Microarray in Melanoma.
Sabel MS, Liu Y, Griffith KA, He J, Xie X, Lubman DM.
Int J Proteomics 2011 Oct; 2011:413742.
Application：Func, Human, Human serum.
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Asah2 Represses the p53-Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis.
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