APBB1 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
APBB1 transfected lysate.
Western Blot
Lane 1: APBB1 transfected lysate ( 77 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-APBB1 full-length
Host
Human
Theoretical MW (kDa)
77
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-APBB1 antibody (H00000322-B01P) by Western Blots.
SDS-PAGE Gel
APBB1 transfected lysate.
Western Blot
Lane 1: APBB1 transfected lysate ( 77 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — APBB1
Entrez GeneID
322GeneBank Accession#
NM_145689Protein Accession#
NP_663722.1Gene Name
APBB1
Gene Alias
FE65, MGC:9072, RIR
Gene Description
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Omim ID
602709Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. [provided by RefSeq
Other Designations
adaptor protein FE65a2|amyloid beta A4 precursor protein-binding, family B, member 1|stat-like protein
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Interactome
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Disease
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