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- Home > Products > siRNA/Chimera > Pre-design Chimera > Angiogenesis > JAG1 Pre-design Chimera RNAi
JAG1 Pre-design Chimera RNAi
- Catalog # : H00000182-R01
- Visit Frequency :
- Size
- Price
- In Stock
- Availability
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- 10 nmol
- USD $ 239
- order now, ship in 2 weeks
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- 20 nmol
- USD $ 289
- order now, ship in 2 weeks
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- The price is valid only in USA. Please select country.
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Email : sales@abnova.com
Phone : +1-909-992-0619 (new)
Fax : +1-909-992-3401- Products will be shipped directly to the customer.
- Specification
- Product Description:
- Homo sapiens jagged 1 (Alagille syndrome) (JAG1), mRNA.
- Reactivity:
- Human
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000214
- Target Region:
- 3' Untranslated Region (3'UTR)
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 182
- Gene Name:
- JAG1
- Gene Alias:
- AGS,AHD,AWS,CD339,HJ1,JAGL1,MGC104644
- Gene Description:
- jagged 1 (Alagille syndrome)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq
- Other Designations:
- OTTHUMP00000030278,jagged 1
- Gene Pathway
- Related Disease
- Alagille Syndrome
- Alzheimer Disease
- Alzheimer disease
- Brain Diseases
- CADASIL
- Cardiovascular Diseases
- Cerebral Amyloid Angiopathy
- Chromosome Deletion
- Cleft Lip
- Cleft Palate
- Diabetes Mellitus, Type 2
- Down Syndrome
- Edema
- Fractures, Bone
- Genetic Predisposition to Disease
- Heart Defects, Congenital
- Hepatitis C
- Kidney Failure, Chronic
- Multiple Sclerosis
