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- Home > Products > siRNA/Chimera > Pre-design Chimera > Membrane > Transporter > A2M Pre-design Chimera RNAi
A2M Pre-design Chimera RNAi
- Catalog # : H00000002-R01
- Visit Frequency :
- Size
- Price
- In Stock
- Availability
- Cart
- 10 nmol
- USD $ 239
- order now, ship in 2 weeks
-
- 20 nmol
- USD $ 289
- order now, ship in 2 weeks
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- The price is valid only in USA. Please select country.
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- Payment Information
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Email : sales@abnova.com
Phone : +1-909-992-0619 (new)
Fax : +1-909-992-3401- Products will be shipped directly to the customer.
- Specification
- Product Description:
- Homo sapiens alpha-2-macroglobulin (A2M), mRNA.
- Reactivity:
- Human
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_000014
- Target Region:
- Coding sequence
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 2
- Gene Name:
- A2M
- Gene Alias:
- CPAMD5,DKFZp779B086,FWP007,S863-7
- Gene Description:
- alpha-2-macroglobulin
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq
- Other Designations:
- -
- Interactome
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Amyloidosis
- Arthritis, Rheumatoid
- Cardiovascular Diseases
- Cognition Disorders
- Dementia
- Diabetes Complications
- Diabetes Mellitus, Type 2
- Disease Progression
- Diseases in Twins
- Edema
- Essential Tremor
- Essential tremor
- Genetic Predisposition to Disease
- Hepatitis C, Chronic
- Kidney Failure, Chronic
- Liver Cirrhosis
- Macular Degeneration
