TFE3 Split FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human renal cell carcinoma (FFPE) stained with TFE3 Split FISH Probe. Human renal cell carcinoma showed TFE3 gene split.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specification
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: TFE3(Texas Red)
Size: Approximately 570kb
Fluorophore: Texas Red
Location: Xp11.22Probe 2
Name: TFE3(FITC)
Size: Approximately 550kb
Fluorophore: FITC
Location: Xp11.22Probe Gap
The gap between two probes is approximately 90 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human renal cell carcinoma (FFPE) stained with TFE3 Split FISH Probe. Human renal cell carcinoma showed TFE3 gene split. -
Gene Info — TFE3
Entrez GeneID
7030Gene Name
TFE3
Gene Alias
RCCP2, TFEA, bHLHe33
Gene Description
transcription factor binding to IGHM enhancer 3
Gene Ontology
HyperlinkGene Summary
TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991 [PubMed 1685140]).[supplied by OMIM
Other Designations
OTTHUMP00000024272|Renal cell carcinoma, papillary|Transcription factor for IgH enhancer|transcription factor E family, member A|transcription factor E3
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Interactome
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Disease
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Publication Reference
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Validation and utilization of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinoma and alveolar soft part sarcoma.
Pradhan D, Roy S, Quiroga-Garza G, Cieply K, Mahaffey AL, Bastacky S, Dhir R, Parwani AV.
Diagnostic Pathology 2015 Sep; 10:179.
Application：FISH, Human, Renal cell carcinomas, Alveolar soft part sarcoma.
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A case study of metastatic Xp11.2 translocation renal cell carcinoma effectively treated with sunitinib.
Numakura K, Tsuchiya N, Yuasa T, Saito M, Obara T, Tsuruta H, Narita S, Horikawa Y, Satoh S, Habuchi T.
International Journal of Clinical Oncology 2010 Dec; 16(5):577.
Application：FISH-P, Human, Renal cell carcinoma.
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Validation and utilization of a TFE3 break-apart FISH assay for Xp11.2 translocation renal cell carcinoma and alveolar soft part sarcoma.
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