MEP50 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human MEP50 full-length ORF ( AAH01679, 1 a.a. - 342 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MRKETPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVRDATWSPLNHSLLTTVGWDHQVVHHVVPTEPLPAPGPASVTE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
63.36
Interspecies Antigen Sequence
Mouse (89)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — WDR77
Entrez GeneID
79084GeneBank Accession#
BC001679Protein Accession#
AAH01679Gene Name
WDR77
Gene Alias
HKMT1069, MEP50, MGC2722, Nbla10071, RP11-552M11.3, p44
Gene Description
WD repeat domain 77
Gene Ontology
HyperlinkGene Summary
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM
Other Designations
OTTHUMP00000013472|androgen receptor cofactor p44|methylosome protein 50
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Interactome
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Publication Reference
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PRMT5 methylating SMAD4 activates TGF-β signaling and promotes colorectal cancer metastasis.
Anyi Liu, Chengxin Yu, Cheng Qiu, Qi Wu, Changsheng Huang, Xun Li, Xiaowei She, Kairui Wan, Lang Liu, Mao Li, Zhihong Wang, Yaqi Chen, Fuqing Hu, Da Song, Kangdi Li, Chongchong Zhao, Haiteng Deng, Xuling Sun, Feng Xu, Senyan Lai, Xuelai Luo, Junbo Hu, Guihua Wang.
Oncogene 2023 May; 42(19):1572.
Application：KA, Recombinant proteins.
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PRMT5 methylating SMAD4 activates TGF-β signaling and promotes colorectal cancer metastasis.
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