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STORY |
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Order online today, and enter your drawing for a chance to win! |
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Need to speak to someone?
Abnova has local lines in 6 countries.
(English Service)
Taiwan
+886-2-8751-1888
USA
+1-909-839-7600
Germany
+49-6221-3632226
UK
+44-2032-869988
Ireland
+353-1-442-9998
Finland
+358-9-2316-3995
Sweden
+46-850-164951 |
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You can contact us by fax
Taiwan
+886-2-6602-1218
USA
+1-909-992-3401
Germany
+49-621-950-0055
UK
+44-2030-311280
Ireland
+353-1-686-5553
Finland
+358-9-2319-4313
Sweden
+46-850-109562 |
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| Immunoperoxidase of monoclonal antibody to TARDBP (Cat # H00023435-M01 ) on formalin-fixed paraffin-embedded human leiomyosarcoma. [antibody concentration 3ug/ml] |
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Gene Information |
| Gene Name: |
TARDBP |
| Gene Description: |
TAR DNA binding protein |
| Gene Alias: |
ALS10; TDP-43 |
| Entrez GeneID: |
23435 |
| Site of Expression |
Brain, Colon, Heart, Kidney, Leukocyte, Liver, Lung, Ovary, Pancreas, Placenta, Prostate, Small intestine, Spleen, Testis, Thymus, Ubiquitous |
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| Immunofluorescence of monoclonal antibody to TARDBP (H00023435-M01) on HeLa cell . [antibody concentration 10ug/ml] |
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Product Information |
| Catalog #: |
H00023435-M01 |
| Product Name: |
TARDBP monoclonal antibody (M01), clone 2E2-D3 |
| Size |
100 ug |
| Application |
IHC-P,
IF,
ELISA,
WB-Ce, WB-Re |
| Related Products |
Antibody:
H00023435-A01
Protein:
H00023435-P01
Chimera: H00023435-R01 |
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| Recent research in neurodegenerative disease has highlighted the importance of a new molecular entity, the TAR DNA binding protein, TDP-43. Prior to the discovery in 2006 that TDP-43 was the target protein in the ubiquitinated cytoplasmic inclusions in neurones in certain histological forms of frontotemporal lobar degeneration (FTLD) known as FTLD-ubiquitinated (FTLD-U), and in motor neurone disease (MND), now it may be a biomarker in plasma. more |
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Reference:
Foulds P et al. (2008) TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration. Mann DM.Acta Neuropathol. 2008 Aug;116(2):141-6. |
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| 19 publications used Abnova product: TARDBP monoclonal antibody (M01), clone 2E2-D3 |
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Ultrastructural localization of TDP-43 in filamentous neuronal inclusions in various neurodegenerative diseases. |
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Maturation process of TDP-43-positive neuronal cytoplasmic inclusions in amyotrophic lateral sclerosis with and without dementia. |
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Enrichment of C-Terminal Fragments in TAR DNA-Binding Protein-43 Cytoplasmic Inclusions in Brain but not in Spinal Cord of Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. |
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A distinct clinical, neuropsychological and radiological phenotype is associated with progranulin gene mutations in a large UK series. |
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Disturbance of nuclear and cytoplasmic Tar DNA binding protein (TDP-43) induces disease-like redistribution, sequestration and aggregate formation. |
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Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43. |
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Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. |
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MAPT S305I mutation: implications for argyrophilic grain disease. |
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FTLD-U linked missense mutations in the progranulin gene reduce progranulin production and secretion. |
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TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia. |
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DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA
and a subset of microRNAs. |
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TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. |
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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic
lateral sclerosis with SOD1 mutations. |
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TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease. |
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TDP-43 is deposited in the Guam parkinsonism-dementia complex brains. |
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TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-
positive inclusions. |
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TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. |
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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. |
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SPOTLIGHT |
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p53 Antibodies
p53 (also known as protein 53 or tumor protein 53), is a transcription factor encoded by the TP53 gene. It is important in multicellular organisms, where it regulates the cell cycle and functions as a tumor suppressor to prevent cancer. We provide Mab, Pab and MaxPab for p53 tumor protein with different applications-WB, IF, IHC, IP, S-ELISA and Det Pair.
See the p53 Antibody list |
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ROS Signaling
Cells are normally able to defend themselves against Reactive oxygen species (ROS) damage through the use of enzymes such as superoxide dismutases
and catalases. Here are antibodies for detecting ROS - Catalase, FDXR, GAPDH, SOD, MPO, PRDX1, TXN and more.
See the ROS Signaling list |
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