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TLR4 polyclonal antibody
- カタログ番号 # : PAB8997
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 41,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
- Immunogen:
- A synthetic peptide corresponding to amino acids 976-998 of human TLR4.
- Sequence:
- DGKSWNPEGTVGTGCNWQEATSI
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:20000)
Dot Blot (1:20000)
Western Blot (1:500)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In buffer containing 0.02% sodium azide
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.
Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T.J Biol Chem. 2003 Dec 12;278(50):49751-62. Epub 2003 Sep 30.
- 2.
- LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.
Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT.J Exp Med. 2003 Oct 6;198(7):1043-55. Epub 2003 Sep 29.
- 3.
- TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T.Nat Immunol. 2003 Feb;4(2):161-7. Epub 2003 Jan 21.
- Application Image
- Western Blot
- ELISA
- Dot Blot
- Entrez GeneID:
- 7099
- Gene Name:
- TLR4
- Gene Alias:
- ARMD10,CD284,TOLL,hToll
- Gene Description:
- toll-like receptor 4
- Omim ID:
- 603030
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
- Other Designations:
- OTTHUMP00000022807,homolog of Drosophila toll
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