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- Home > Products > Polyclonal Ab > Human > Cell Cycle > CDKN1B polyclonal antibody
CDKN1B polyclonal antibody
- カタログ番号 # : PAB5497
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of CDKN1B.
- Immunogen:
- A synthetic peptide corresponding to residues surrounding S10 of human CDKN1B.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions.
McAllister SS, Becker-Hapak M, Pintucci G, Pagano M, Dowdy SF.Mol Cell Biol. 2003 Jan;23(1):216-28.
- 2.
- CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.
Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM.Mol Biol Cell. 2003 Jan;14(1):201-13.
- 3.
- Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1.
Chopra S, Fernandez De Mattos S, Lam EW, Mann DJ.J Biol Chem. 2002 Sep 6;277(36):32413-6. Epub 2002 Jul 15.
- Entrez GeneID:
- 1027
- Gene Name:
- CDKN1B
- Gene Alias:
- CDKN4,KIP1,MEN1B,MEN4,P27KIP1
- Gene Description:
- cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
- Other Designations:
- cyclin-dependent kinase inhibitor 1B
- Related Disease
- Acromegaly
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- Alzheimer disease
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- Breast Neoplasms
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- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Papillary, Follicular
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- Cognition
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- Colorectal Neoplasms
