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- Home > Products > Polyclonal Ab > Human > Cell Ad/Junc/Cytoskel > S1PR1 polyclonal antibody
S1PR1 polyclonal antibody
- カタログ番号 # : PAB4718
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of S1PR1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human S1PR1.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor.
Dorsam G, Graeler MH, Seroogy C, Kong Y, Voice JK, Goetzl EJ.J Immunol. 2003 Oct 1;171(7):3500-7.
- 2.
- Inhibition of Ca(2+) signalling by the sphingosine 1-phosphate receptor S1P(1).
zu Heringdorf DM, Vincent ME, Lipinski M, Danneberg K, Stropp U, Wang DA, Tigyi G, Jakobs KH.Cell Signal. 2003 Jul;15(7):677-87.
- 3.
- Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2.
Watterson KR, Johnston E, Chalmers C, Pronin A, Cook SJ, Benovic JL, Palmer TM.J Biol Chem. 2002 Feb 22;277(8):5767-77. Epub 2001 Dec 6.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of mouse lung tissue lysate (35 ug/lane) with S1PR1 polyclonal antibody (Cat # PAB4718).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with S1PR1 polyclonal antibody (Cat # PAB4718) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 1901
- Protein Accession#:
- NP_001391
- Gene Name:
- S1PR1
- Gene Alias:
- CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,FLJ58121,S1P1
- Gene Description:
- sphingosine-1-phosphate receptor 1
- Omim ID:
- 601974
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq
- Other Designations:
- G protein-coupled sphingolipid receptor,OTTHUMP00000012525,endothelial differentiation, sphingolipid G-protein-coupled receptor, 1,sphingosine 1-phosphate receptor EDG1
- Gene Pathway
