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- Home > Products > Polyclonal Ab > Human > Signal Transduction > PIK3CG polyclonal antibody
PIK3CG polyclonal antibody
- カタログ番号 # : PAB4069
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of PIK3CG.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human PIK3CG.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The IL-1 receptor accessory protein is essential for PI 3-kinase recruitment and activation.
Reddy SA, Lin YF, Huang HJ, Samanta AK, Liao WS.Biochem Biophys Res Commun. 2004 Apr 16;316(4):1022-8.
- 2.
- Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Andreozzi F, D'Alessandris C, Federici M, Laratta E, Del Guerra S, Del Prato S, Marchetti P, Lauro R, Perticone F, Sesti G.Endocrinology. 2004 Jun;145(6):2845-57. Epub 2004 Mar 4.
- 3.
- Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45.
Osaki M, Kase S, Adachi K, Takeda A, Hashimoto K, Ito H.J Cancer Res Clin Oncol. 2004 Jan;130(1):8-14. Epub 2003 Nov 7.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of PIK3CG polyclonal antibody (Cat # PAB4069) in HeLa cell lysate (35 ug/lane). PIK3CG (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Western Blot (Transfected lysate)
- Western blot analysis of PIK3CG polyclonal antibody (Cat # PAB4069) in 293 cell lysate transiently transfected with the PIK3CG gene (2 ug/lane). PIK3CG (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human muscle tissue reacted with PIK3CG polyclonal antibody (Cat # PAB4069) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 5294
- Protein Accession#:
- NP_002640;P48736
- Gene Name:
- PIK3CG
- Gene Alias:
- PI3CG,PI3K,PI3Kgamma,PIK3
- Gene Description:
- phosphoinositide-3-kinase, catalytic, gamma polypeptide
- Omim ID:
- 601232
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq
- Other Designations:
- 1-phosphatidylinositol 3-kinase,PI3-kinase,PTDINS-3-kinase,p110-gamma,phosphatidylinositol 3 kinase gamma, p110 gamma,phosphatidylinositol 3-kinase catalytic 110-kD gamma,phosphatidylinositol 3-kinase, catalytic, gamma polypeptide,phosphoinositide-3-kinas
- Gene Pathway
- Acute myeloid leukemia
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- Glioma
- Inositol phosphate metabolism
- Insulin signaling pathway
- Jak-STAT signaling pathway
- Leukocyte transendothelial migration
- Melanoma
- mTOR signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
