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MAP2K2 polyclonal antibody
- カタログ番号 # : PAB3174
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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Phone : +886-2-87511888
Fax : +886-2-87511166- 製品は、お客様に直接出荷されます。
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAP2K2.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to internal region of human MAP2K2.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2.
Tran H, Maurer F, Nagamine Y.Mol Cell Biol. 2003 Oct;23(20):7177-88.
- 2.
- p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2.
Li SP, Junttila MR, Han J, Kahari VM, Westermarck J.Cancer Res. 2003 Jul 1;63(13):3473-7.
- 3.
- Phosphatidylinositol 3-kinase and mek1/2 are necessary for insulin-like growth factor-I-induced vascular endothelial growth factor synthesis in prostate epithelial cells: a role for hypoxia-inducible factor-1?
Burroughs KD, Oh J, Barrett JC, DiAugustine RP.Mol Cancer Res. 2003 Feb;1(4):312-22.
- Applications
- Western Blot (Tissue lysate)
- The MAP2K2 polyclonal antibody (Cat # PAB3174) is used in Western blot to detect MAP2K2 in mouse liver tissue lysate.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with MAP2K2 polyclonal antibody (Cat # PAB3174) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 5605
- Protein Accession#:
- P36507
- Gene Name:
- MAP2K2
- Gene Alias:
- FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2
- Gene Description:
- mitogen-activated protein kinase kinase 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq
- Other Designations:
- ERK activator kinase 2,MAP kinase kinase 2,MAPK/ERK kinase 2,dual specificity mitogen-activated protein kinase kinase 2,mitogen-activated protein kinase kinase 2, p45
- Gene Pathway
- Acute myeloid leukemia
- B cell receptor signaling pathway
- Bladder cancer
- Chronic myeloid leukemia
- Endometrial cancer
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Gap junction
- Glioma
- GnRH signaling pathway
- Insulin signaling pathway
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Non-small cell lung cancer
- Pathways in cancer
- Prion diseases
- Prostate cancer
- Regulation of actin cytoskeleton
- Renal cell carcinoma
- T cell receptor signaling pathway
- Thyroid cancer
- Toll-like receptor signaling pathway
- Vascular smooth muscle contraction
- VEGF signaling pathway
