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ACVR2B polyclonal antibody
- カタログ番号 # : PAB2022
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ACVR2B.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVR2B.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Modulation of noncanonical TGF-?] signaling prevents cleft palate in Tgfbr2 mutant mice.
Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y.J Clin Invest. 2012 Mar 1;122(3):873-85. doi: 10.1172/JCI61498. Epub 2012 Feb 13.
- 2.
- An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.
Harrison CA, Gray PC, Fischer WH, Donaldson C, Choe S, Vale W.J Biol Chem. 2004 Jul 2;279(27):28036-44. Epub 2004 Apr 27.
- 3.
- Expression of activin subunits and receptors in the developing human ovary: activin A promotes germ cell survival and proliferation before primordial follicle formation.
Martins da Silva SJ, Bayne RA, Cambray N, Hartley PS, McNeilly AS, Anderson RA.Dev Biol. 2004 Feb 15;266(2):334-45.
- 4.
- Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia.
Casagrandi D, Bearfield C, Geary J, Redman CW, Muttukrishna S.Mol Hum Reprod. 2003 Apr;9(4):199-203.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of ACVR2B polyclonal antibody (Cat # PAB2022) in mouse heart, kidney and brain lysates (35 ug/lane). ACVR2B (arrow) was detected using the purified Polyclonal antibody.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVR2B polyclonal antibody (Cat # PAB2022) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
- Entrez GeneID:
- 93
- Protein Accession#:
- NP_001097;Q13705
- Gene Name:
- ACVR2B
- Gene Alias:
- ACTRIIB,ActR-IIB,MGC116908
- Gene Description:
- activin A receptor, type IIB
- Omim ID:
- 602730
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq
- Other Designations:
- activin A type IIB receptor
