Rabbit polyclonal antibody raised against synthetic peptide of HDAC1.
Immunogen:
A synthetic peptide corresponding to residues surrounding S421/S423 of human HDAC1.
Host:
Rabbit
Reactivity:
Human, Mouse, Rat
Specificity:
This antibody detects endogenous levels of total HDAC1 protein.
Form:
Liquid
Recommend Usage:
Western Blot (1:500-1:1000) Immunohistochemistry (1:50-1:100) ELISA (1:20000) The optimal working dilution should be determined by the end user.
Storage Buffer:
In 20 mM PBS, 0.15 M NaCl, pH 7.2 (0.01% sodium azide)
Storage Instruction:
Store at 4°C for three months. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Publication Reference
1.
A quantitative atlas of mitotic phosphorylation. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP.Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. Epub 2008 Jul 31.
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq