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- Home > Products > Polyclonal Ab > Human > Apoptosis > MAPT polyclonal antibody
MAPT polyclonal antibody
- カタログ番号 # : PAB14198
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 150 uL
- JPY ¥ 41,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of MAPT.
- Immunogen:
- A synthetic peptide corresponding to human MAPT.
- Host:
- Rabbit
- Reactivity:
- Human
- Specificity:
- This antibody specifically detects phosphorylated protein derived from human brain tissue. It recognizes PHF-tau phosphorylated at Thr231. In both ELISA and WB, this antibody shows no cross-reactivity with other unrelated protein.
- Form:
- Liquid
- Recommend Usage:
- ELISA (1:5000-1:10000)
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (50% glycerol, 0.1% BSA)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Publication Reference
- 1.
- NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies.
Arima K, Mizutani T, Alim MA, Tonozuka-Uehara H, Izumiyama Y, Hirai S, Ueda K.Acta Neuropathol. 2000 Aug;100(2):115-21.
- 2.
- Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.
Gong CX, Grundke-Iqbal I, Iqbal K.Neuroscience. 1994 Aug;61(4):765-72.
- 3.
- The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.
Biernat J, Mandelkow EM, Schroter C, Lichtenberg-Kraag B, Steiner B, Berling B, Meyer H, Mercken M, Vandermeeren A, Goedert M, et al..EMBO J. 1992 Apr;11(4):1593-7.
- Application Image
- Western Blot
- Immunoprecipitation
- ELISA
- Entrez GeneID:
- 4137
- Gene Name:
- MAPT
- Gene Alias:
- DDPAC,FLJ31424,FTDP-17,MAPTL,MGC138549,MSTD,MTBT1,MTBT2,PPND,TAU
- Gene Description:
- microtubule-associated protein tau
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq
- Other Designations:
- G protein beta1/gamma2 subunit-interacting factor 1,microtubule-associated protein tau, isoform 4
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Amyloidosis
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Aphasia, Primary Progressive
- Atherosclerosis
- Atherosclerosis
- Atrophy
- Autistic Disorder
- Brain Concussion
- Brain Diseases
- Brain Ischemia
- Cardiovascular Diseases
- Carotid Stenosis
- Cleft Lip
- Cleft Palate
- Cognition
- Cognition Disorders
