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- Home > Products > Polyclonal Ab > Human > Signal Transduction > APH1A polyclonal antibody
APH1A polyclonal antibody
- カタログ番号 # : PAB13237
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of APH1A.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 13 amino acids of human APH1A.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.
Ma G, Li T, Price DL, Wong PC.J Neurosci. 2005 Jan 5;25(1):192-8.
- 2.
- Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.J Neurosci Res. 2004 Aug 1;77(3):309-22.
- 3.
- APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
Goutte C, Tsunozaki M, Hale VA, Priess JR.Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):775-9. Epub 2002 Jan 15.
- Entrez GeneID:
- 51107
- Protein Accession#:
- AAH08732
- Gene Name:
- APH1A
- Gene Alias:
- 6530402N02Rik,APH-1A,CGI-78
- Gene Description:
- anterior pharynx defective 1 homolog A (C. elegans)
- Omim ID:
- 607629
- Gene Ontology:
- Hyperlink
- Gene Summary:
- APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
- Other Designations:
- OTTHUMP00000014528,OTTHUMP00000014529,anterior pharynx defective 1 homolog A
- Gene Pathway
