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- Home > Products > Polyclonal Ab > Phospho-Specific > APBB1 (phospho S347) polyclonal antibody
APBB1 (phospho S347) polyclonal antibody
- カタログ番号 # : PAB0407
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 41,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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Phone : +886-2-87511888
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of APBB1.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S347 of human APBB1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
Kinoshita A, Shah T, Tangredi MM, Strickland DK, Hyman BT.J Biol Chem. 2003 Oct 17;278(42):41182-8. Epub 2003 Jul 29.
- 2.
- gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ.Biochemistry. 2003 Jun 10;42(22):6664-73.
- 3.
- The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway.
Zhao Q, Lee FS.Biochemistry. 2003 Apr 1;42(12):3627-34.
- Entrez GeneID:
- 322
- Protein Accession#:
- NP_001155.1;O00213
- Gene Name:
- APBB1
- Gene Alias:
- FE65,MGC:9072,RIR
- Gene Description:
- amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
- Omim ID:
- 602709
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. [provided by RefSeq
- Other Designations:
- adaptor protein FE65a2,amyloid beta A4 precursor protein-binding, family B, member 1,stat-like protein
- Gene Pathway
