Western blot analysis of HDAC1polyclonal antibody (Cat # PAB0001) .
Immunoprecipitation
Measurement of HeLa cell endogenous HDAC1 in an immunoprecipitate using HDAC1polyclonal antibody (Cat # PAB0001) by means of HDACs Deacetylase Fluorometric (Human) Assay Kit (Cat # KA0104).
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq