Mouse monoclonal antibody raised against native PTPRC.
Native purified PTPRC from T-cell line CA1.
The monoclonal antibody is directed against the 180 kD CD45RO-antigen (restricted T200), a component of the Leucocyte Common Antigen (LCA) complex, which is expressed on human T-lymphocytes (40% of CD4 and 20% of CD8 positive T-lymphocytes), most thymocytes and the majority of T-cell malignancies. The monoclonal antibody also reacts with most human granulocytes and monocytes but reacts hardly with B-lymphocytes, NK-cells or Thrombocytes. Meanwhile, immunostaining on paraffin tissues has indicated that the monoclonal antibody reacts with normal T-lymphocytes, most T-cell related tumours, true histocytic lymphomas and granulocytic sarcomas but not with B-cell related tumours.
The optimal working dilution should be determined by the end user.
In tissue culture supernatant (8% FBS, 0.09% sodium azide)
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq
CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptide