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RAF1 monoclonal antibody, clone PS338 [DPR/2/2A/3A]   

  • カタログ番号 # : MAB5144
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  • サイズ
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  • 100 ug
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against synthetic peptide of RAF1.
  • Immunogen:
  • A synthetic peptide corresponding to human RAF1.
  • Sequence:
  • GQRDSSYYWEIEAS
  • Host:
  • Rat
  • Reactivity:
  • Human
  • Specificity:
  • This antibody binds to phosphorylated serine residue at aa 338. It does not bind to unactivated Raf-1 or Raf-1 phosphorylated at Y341 and S339. Molecular weight 74 KDa.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (2-4 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, pH 7.4 (0.09% sodium azide, BSA)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Formalin-fixed, paraffin-embedded human tonsil stained with RAF1 monoclonal antibody, clone PS338 [DPR/2/2A/3A] (Cat # MAB5144) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of mucous epithelium.
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5894
  • Gene Name:
  • RAF1
  • Gene Alias:
  • CRAF,NS5,Raf-1,c-Raf
  • Gene Description:
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • Gene Summary:
  • This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq
  • Other Designations:
  • Oncogene RAF1,raf proto-oncogene serine/threonine protein kinase
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