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KLK3 monoclonal antibody, clone 131-14234   

  • カタログ番号 # : MAB4310
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  • サイズ
  • 価格
  • 在庫あ
  • 入手可能
  • カート
  • 100 ug
  • JPY ¥ 39,000
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    1. この価格は、 Japanでのみ有効です。国を選択して下さい。
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native KLK3.
  • Immunogen:
  • Native purified human KLK3.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • human Prostate Specific Antigen (PSA). PSA is a tumor-associated antigen with a molecular weight of 34 KDa. The antigen is found in normal prostatic epithelial lining cells of the ducts and acini, as well as in primary and metastatic prostate carcinoma cells. PSA reactivity may also be found in BPH (benign prostatic hypertrophy), though the pattern of staining is different than that found in carcinoma tissues. The staining pattern ranges from cytoplasmic and secretory in normal and benign prostate to cytoplasmic with membrane in neoplastic prostate.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM phosphate buffer, pH 7.4 (150 mM NaCl, 0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 354
  • Gene Name:
  • KLK3
  • Gene Alias:
  • APS,KLK2A1,PSA,hK3
  • Gene Description:
  • kallikrein-related peptidase 3
  • Gene Summary:
  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • P-30 antigen,gamma-seminoprotein,kallikrein 3, (prostate specific antigen),prostate specific antigen,semenogelase,seminin
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