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- Home > Products > Monoclonal Ab > Human > Apoptosis > APAF1 monoclonal antibody, clone 2E10
APAF1 monoclonal antibody, clone 2E10
- カタログ番号 # : MAB2746
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 39,000
- order now, ship in 5 days
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Mouse monoclonal antibody raised against synthetic peptide of APAF1.
- Immunogen:
- A synthetic peptide corresponding to amino acids near C-terminus of human APAF1.
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Isotype:
- IgG
- Recommend Usage:
- Western Blot (0.25-0.5 mg/mL)
The optimal working dilution should be determined by the end user.
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.
Cecconi F, Alvarez-Bolado G, Meyer BI, Roth KA, Gruss P.Cell. 1998 Sep 18;94(6):727-37.
- 2.
- Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Hu Y, Benedict MA, Wu D, Inohara N, Nunez G.Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4386-91.
- 3.
- Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X.Cell. 1997 Nov 14;91(4):479-89.
- Entrez GeneID:
- 317
- Protein Accession#:
- n/a
- Gene Name:
- APAF1
- Gene Alias:
- CED4,DKFZp781B1145
- Gene Description:
- apoptotic peptidase activating factor 1
- Omim ID:
- 602233
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- apoptotic protease activating factor 1
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