Mouse monoclonal antibody raised against recombinant EGFR.
Immunogen:
Recombinant protein corresponding to extracellular region of human EGFR.
Host:
Mouse
Theoretical MW (kDa):
170, 145
Reactivity:
Human
Specificity:
This antibody recognizes 170 KDa for wild type EGFR and 145 KDa for VIII variant.
Form:
Liquid
Purification:
Protein A purification
Concentration:
Lot specific
Isotype:
IgG1
Quality Control Testing:
Antibody Reactive Against Recombinant Protein.
Recommend Usage:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (Formalin/PFA-fixed paraffin-embedded sections) (1:50) The optimal working dilution should be determined by the end user.
Storage Buffer:
In 10 mM PBS, pH 7.4 (1% BSA, 0.1% sodium azide)
Storage Instruction:
Store at 4°C.
Note:
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
Other Designations:
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor