Western blot analysis using SRC monoclonal antibody, clone 28 (Cat # MAB2021),on MCF-7 (1), mouse 3T3-L1 (2) and rat PC-12 (3) cell lysates. Antibody used at1 ug/mL .
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq