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- Home > Products > Monoclonal Ab > Human > Enzyme > Others > COX4I2 monoclonal antibody (M01), clone 1F2
COX4I2 monoclonal antibody (M01), clone 1F2
- カタログ番号 # : H00084701-M01
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 40,000
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant COX4I2.
- Immunogen:
- COX4I2 (NP_115998, 21 a.a. ~ 104 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- MHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAEEQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKT
- Host:
- Mouse
- Reactivity:
- Human
- Isotype:
- IgG2a Kappa
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (34.98 KDa) .
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- MSDS:
Download
- Publication Reference
- 1.
- Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
Aras S, Pak O, Sommer N, Finley R Jr, Huttemann M, Weissmann N, Grossman LI.Nucleic Acids Res. 2013 Jan 8.
- 2.
- Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
Huttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Schrewe A, Sun M, Hofler H, Adamski J, Bekeredjian R, Graw J, Adler T, Busch DH, Klingenspor M, Klopstock T, Ollert M, Wolf E, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Weissmann N, Doan JW, Bassett DJ, Grossman LI.FASEB J. 2012 Sep;26(9):3916-30. Epub 2012 Jun 22.
- 3.
- Sex- and brain region-specific role of cytochrome c oxidase in 1-methyl-4-phenylpyridinium-mediated astrocyte vulnerability.
Sundar Boyalla S, Barbara Victor M, Roemgens A, Beyer C, Arnold S.J Neurosci Res. 2011 Dec;89(12):2068-82. doi: 10.1002/ jnr.22669. Epub 2011 May 19.
- 4.
- Brain region-specific vulnerability of astrocytes in response to 3-nitropropionic acid is mediated by cytochrome c oxidase isoform expression.
Misiak M, Singh S, Drewlo S, Beyer C, Arnold S.Cell Tissue Res. 2010 Jul;341(1):83-93. Epub 2010 Jul 3.
- 5.
- Brain region specificity of 3-nitropropionic acid-induced vulnerability of neurons involves cytochrome c oxidase.
Singh S, Misiak M, Beyer C, Arnold S.Neurochem Int. 2010 Jun 23. [Epub ahead of print]
- Applications
- Western Blot (Transfected lysate)
- Western Blot analysis of COX4I2 expression in transfected 293T cell line by COX4I2 monoclonal antibody (M01), clone 1F2.
Lane 1: COX4I2 transfected lysate(20 KDa).
Lane 2: Non-transfected lysate. - Protocol Download
- Western Blot (Recombinant protein)
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to COX4I2 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml]
- Protocol Download
- Immunoprecipitation
- Immunoprecipitation of COX4I2 transfected lysate using anti-COX4I2 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with COX4I2 MaxPab rabbit polyclonal antibody.
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged COX4I2 is 0.03 ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 84701
- GeneBank Accession#:
- NM_032609
- Protein Accession#:
- NP_115998
- Gene Name:
- COX4I2
- Gene Alias:
- COX4,COX4-2,COX4B,COX4L2,COXIV-2,dJ857M17.2
- Gene Description:
- cytochrome c oxidase subunit IV isoform 2 (lung)
- Omim ID:
- 607976
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq
- Other Designations:
- OTTHUMP00000030533,cytochrome c oxidase subunit IV isoform 2,cytochrome c oxidase subunit IV-like 2
- Related Disease
