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- Home > Products > Proteins/Peptides > Human > Partial-length > Apoptosis > MAP3K5 (Human) Recombinant Protein (Q01)
MAP3K5 (Human) Recombinant Protein (Q01)
- カタログ番号 # : H00004217-Q01
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
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- カート
- 10 ug
- JPY ¥ 40,000
- order now, ship next day
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- 25 ug
- JPY ¥ 59,000
- order now, ship next day
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Human MAP3K5 partial ORF ( AAH54503, 1231 a.a. - 1374 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- SHDSQSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVNGADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT
- Theoretical MW (kDa):
- 41.58
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 4217
- GeneBank Accession#:
- BC054503
- Protein Accession#:
- AAH54503
- Gene Name:
- MAP3K5
- Gene Alias:
- ASK1,MAPKKK5,MEKK5
- Gene Description:
- mitogen-activated protein kinase kinase kinase 5
- Omim ID:
- 602448
- Gene Ontology:
- Hyperlink
- Gene Summary:
- Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq
- Other Designations:
- MAP/ERK kinase kinase 5,MAPK/ERK kinase kinase 5,OTTHUMP00000017275,apoptosis signal regulating kinase
- Interactome
