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- Home > Products > Monoclonal Ab > Human > Enzyme > Kinase > FGFR2 monoclonal antibody (M01), clone 1G3
FGFR2 monoclonal antibody (M01), clone 1G3
- カタログ番号 # : H00002263-M01
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 100 ug
- JPY ¥ 40,000
- order now, ship next day
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- この価格は、 Japanでのみ有効です。国を選択して下さい。
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- Specification
- Product Description:
- Mouse monoclonal antibody raised against a partial recombinant FGFR2.
- Immunogen:
- FGFR2 (AAH39243, 621 a.a. ~ 723 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
- Sequence:
- GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYEPCLPQYPHINGSVKT
- Host:
- Mouse
- Reactivity:
- Human
- Specificity:
- This antibody also cross-reacts with human FGFR1, FGFR3.
- Isotype:
- IgG2b kappa
- Quality Control Testing:
- Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.07 KDa) .
- Storage Buffer:
- In 1x PBS, pH 7.2
- Storage Instruction:
- Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
- MSDS:
Download
- Publication Reference
- 1.
- The expression of fibroblast growth factor receptors during early bovine conceptus development and pharmacological analysis of their actions on trophoblast growth in vitro.
Ozawa M, Yang QE, Ealy AD.Reproduction. 2013 Jan 24;145(2):191-201. doi: 10.1530/REP-12-0220. Print 2013.
- 2.
- Differential expression of growth factor receptors and membrane-bound tumor markers for imaging in male and female breast cancer.
Vermeulen JF, Kornegoor R, van der Wall E, van der Groep P, van Diest PJ.PLoS One. 2013;8(1):e53353. doi: 10.1371/journal.pone.0053353. Epub 2013 Jan 4.
- Applications
- Western Blot (Recombinant protein)
- Protocol Download
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Immunoperoxidase of monoclonal antibody to FGFR2 on formalin-fixed paraffin-embedded human stomach carcinoma tissue. [antibody concentration 5 ug/ml]
- Protocol Download
- Sandwich ELISA (Recombinant protein)
- Detection limit for recombinant GST tagged FGFR2 is approximately 0.03ng/ml as a capture antibody.
- Protocol Download
- Entrez GeneID:
- 2263
- GeneBank Accession#:
- BC039243
- Protein Accession#:
- AAH39243
- Gene Name:
- FGFR2
- Gene Alias:
- BEK,BFR-1,CD332,CEK3,CFD1,ECT1,FLJ98662,JWS,K-SAM,KGFR,TK14,TK25
- Gene Description:
- fibroblast growth factor receptor 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
- Other Designations:
- BEK fibroblast growth factor receptor,FGF receptor,OTTHUMP00000020621,OTTHUMP00000020629,bacteria-expressed kinase,hydroxyaryl-protein kinase,keratinocyte growth factor receptor,protein tyrosine kinase, receptor like 14,soluble FGFR4 variant 4
- Interactome
- Related Disease
- Acrocephalosyndactylia
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Alzheimer Disease
- Alzheimer disease
- Birth Weight
- Breast cancer
- Breast Neoplasms
- Bronchial Hyperreactivity
- Carcinoma, Basal Cell
- Carcinoma, Endometrioid
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Craniofacial Dysostosis
- Craniosynostoses
- Cystadenocarcinoma, Serous
- Depressive Disorder, Major
