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- Home > Products > siRNA/Chimera > Pre-design Chimera > Cell Cycle > CDKN1B Pre-design Chimera RNAi
CDKN1B Pre-design Chimera RNAi
- カタログ番号 # : H00001027-R01
- 頻繁に訪問する :
- サイズ
- 価格
- 在庫あ
- 入手可能
- カート
- 10 nmol
- ..........
- 20 nmol
- ..........
-
- This product is not available in Japan.
- お問い合わせ
-
Contact Information
Email : sales@abnova.com
Phone : +886-2-87511888
Fax : +886-2-87511166
- Specification
- Product Description:
- Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1) (CDKN1B), mRNA.
- Reactivity:
- Human
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_004064
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1027
- Gene Name:
- CDKN1B
- Gene Alias:
- CDKN4,KIP1,MEN1B,MEN4,P27KIP1
- Gene Description:
- cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq
- Other Designations:
- cyclin-dependent kinase inhibitor 1B
- Related Disease
- Acromegaly
- Adenocarcinoma
- Adenocarcinoma, Follicular
- Alzheimer Disease
- Alzheimer disease
- Ataxia telangiectasia
- Atherosclerosis
- Breast cancer
- Breast Neoplasms
- Carcinoma
- Carcinoma, Ductal, Breast
- Carcinoma, Hepatocellular
- Carcinoma, Papillary, Follicular
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Chromosome Aberrations
- Cognition
- Colon cancer
- Colorectal Neoplasms
